A network of experts in reproductive and children’s environmental health

PEHSU Journal Club Webinar

This in-depth and interactive series provides a platform for learning and discussion about issues that focus on current and emerging aspects of pediatric and reproductive environmental health.

Hormesis: Do Little Things Matter?-November 18, 2015 - 1PM EDT

The presenter will begin by describing the study methodologies used in the journal articles to be discussed. This will be followed by a discussion of the results of the studies under consideration and implications for current clinical and public health practice. The presenter will conclude by discussing preventive steps that can be taken to decrease exposure to endocrine disruptors as evidenced in the journal articles.

Articles to be discussed:

1. Evidence for hormesis in mutagenicity dose-response relationships.
Calabrese EJ, Stanek EJ 3rd, and Nascarella MA
Mutation Research 2011; 726(2): 91-97

2. An illusion of hormesis in the Ames test: Statistical significance is not equivalent to biological significance.
Zeiger E and Hoffmann GR
Mutation Research 2012; 746(1): 89-93

3. The Frequency of U-Shaped Dose Responses in the Toxicological Literature. 
Calabrese EJ and Baldwin LA 
Toxicological Sciences 2001; 62: 330-338

4. Natural Variability and the Influence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities.
Ashby J, Tinwell H, Odum J, and Lefevre P
Environmental Health Perspectives; 112(8): 847-853

Learning Objectives

At the conclusion of this activity, attendees should be able to:
  • Understand the theory of hormesis
  • Explain the controversy of hormesis as described in the Ames Test research
  • Describe how natural variability may influence research on hormesis

Presenter: Jennifer Lowry, MD, FACMT 

J Lowry photoJennifer Lowry, MD, FACMT
Medical Director, Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation
University of Washington
Children's Mercy Kansas City
Kansas City, MO
Jennifer Lowry, MD, FACMT, attended medical school at the University of South Dakota School of Medicine in Vermillion and Rapid City, South Dakota. Subsequently, she completed a Pediatric Residency and Clinical Pharmacology/Medical Toxicology Fellowship at the Children's Mercy Hospital and Clinics in Kansas City, MO. She is board certified in Pediatrics and Medical Toxicology. She spent 5 years at the University of Kansas Medical Center as the Medical Director to the University of Kansas Hospital Poison Control Center. Currently, she is the Chief for the Section of Clinical Toxicology at Children's Mercy Hospital and an Associate Professor in Pediatrics at the University of Missouri \u2013 Kansas City School of Medicine. She continues to serve as a toxicologist for the KUH-PCC.

She has served as the Director for the Mid-America Pediatric Environmental Health Specialty Unit for EPA Region 7 (Iowa, Kansas, Missouri and Nebraska) since its inception in 2002 and as a medical toxicology liaison to the Region 7 Agency for Toxic Substances and Disease Registry. She is a current member of the Children's Health Protection Advisory Committee for the Environmental Protection Agency and the Chair-Elect for the American Academy of Pediatrics' Council on Environmental Health.

She is a frequently invited lecturer on pediatric toxicology and environmental exposures in the region. In addition, she has been Co-Director to multiple courses on toxicology and pediatric environmental health.

Webinar Recording and Materials

 Preview.png Take_Course_Button.png

Continuing Education 

To receive continuing education (CE):

FEES: No fees are charged for CDC’s CE activities. 


CME activities with Joint Providers: This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of the Centers for Disease Control and Prevention and the American College of Medical Toxicology. The Centers for Disease Control and Prevention is accredited by the (ACCME®) to provide medical education for physicians. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Regarding WC2611 - The Centers for Disease Control and Prevention designates this live educational activity for a maximum of 1.0 AMA PRA Category 1 Credits™.

Regarding WD2611 - The Centers for Disease Control and Prevention designates this enduring material for a maximum of1.0 AMA PRA Category 1 Credits™.

Other Credit types:

  • CNE: The Centers for Disease Control and Prevention is accredited as a provider of Continuing Nursing Education by the American Nurses Credentialing Center's Commission on Accreditation. This activity provides 1.0 contact hours.
  • CEU: The Centers for Disease Control and Prevention is authorized by IACET to offer 1.0 CEU's for this program.
  • CECH: Sponsored by the Centers for Disease Control and Prevention, a designated provider of continuing education contact hours (CECH) in health education by the National Commission for Health Education Credentialing, Inc. This program is designated for Certified Health Education Specialists (CHES) and/or Master Certified Health Education Specialists (MCHES) to receive up to1.0 total Category I continuing education contact hours. Maximum advanced level continuing education contact hours available are 0. CDC provider number GA0082.
  • For Certified Public Health Professionals (CPH)
    CDC is an approved provider of CPH Recertification Credits by the National Board of Public Health Examiners. Effective October 1, 2013, the National Board of Public Health Examiners (NBPHE) accepts continuing education units (CEU) for CPH recertification credits from CDC. Please select CEU as your choice for continuing education when registering for a course on TCEOnline. Learners seeking CPH should use the guidelines provided by the NBPHE for calculating recertification credits. For assistance please contact NBPHE at http://www.NBPHE.org.


This material was supported by the American College of Medical Toxicology (ACMT) and funded (in part) by the cooperative agreement FAIN: U61TS000238-02 from the Agency for Toxic Substances and Disease Registry (ATSDR). 

Acknowledgement: The U.S. Environmental Protection Agency (EPA) supports the PEHSU by providing partial funding to ATSDR under Inter-Agency Agreement number DW-75-95877701. Neither EPA nor ATSDR endorse the purchase of any commercial products or services mentioned in PEHSU publications

DISCLOSURE: In compliance with continuing education requirements, all presenters must disclose any financial or other associations with the manufacturers of commercial products, suppliers of commercial services, or commercial supporters as well as any use of unlabeled product(s) or product(s) under investigational use.

CDC, our planners, presenters, and their spouses/partners wish to disclose they have no financial interests or other relationships with the manufacturers of commercial products, suppliers of commercial services, or commercial supporters with the exception of Charles A. McKay and he wishes to disclose that he is a member of the Scientific Advisory Council, Environmental Health Research Foundation (EHRF). EHRF addresses issues related to biomonitoring, a topic that is also relevant to some of the activities in the Grand Round Series that might be discussed in future sessions. EHRF receives funding from sources that includes industry. Dr. McKay has reviewed and written material for EHRF, that could create a perceived conflict of interest regarding environmental chemical exposure assessment/measurement.

Planning committee discussed conflict of interest with Dr. Charles A. McKay to ensure there is no bias. Content will not include any discussion of the unlabeled use of a product or a product under investigational use. CDC does not accept commercial support.