- Understand the theory of hormesis
- Explain the controversy of hormesis as described in the Ames Test research
- Describe how natural variability may influence research on hormesis
1. Evidence for hormesis in mutagenicity dose-response relationships.
Calabrese EJ, Stanek EJ 3rd, and Nascarella MA
Mutation Research 2011; 726(2): 91-97
2. An illusion of hormesis in the Ames test: Statistical significance is not equivalent to biological significance.
Zeiger E and Hoffmann GR
Mutation Research 2012; 746(1): 89-93
3. The Frequency of U-Shaped Dose Responses in the Toxicological Literature.
Calabrese EJ and Baldwin LA
Toxicological Sciences 2001; 62: 330-338
4. Natural Variability and the Inﬂuence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities.
Ashby J, Tinwell H, Odum J, and Lefevre P