This course is part of a series of short courses offered by the American College of Medical Toxicology on contemporary issues in environmental toxicology and environmental health developed by leading authorities in medical toxicology under the direction of Drs. Michael Kosnett, Charles McKay and Paul Wax.
- Describe the carcinogenicity classifications of various agencies (i.e. IARC, ACGIH, NTP, NIOSH), methods for determining the classification status of a given agent, nuances of individual definitions, and scientific uncertainty associated with classification
- Distinguish between exposure and dose and describe the importance of intensity, chronicity, route, and individual and population susceptibility on carcinogenicity
- Understand the fundamentals underlying various in vitro mutagenicity and carcinogenicity studies, laboratory animal studies, and human epidemiology or surveillance studies and the strength and limitations of each of these modalities
- Familiarity with EPA computational models for distribution of toxicants in various media, physical and chemical properties that affect distribution, the use of models in risk assessment, and their limitations
- Describe the four components of risk assessment, extrapolation and the use of protection factors, and the scientific uncertainties associated with risk assessment
Funding for this web-based learning module was made possible (in part) by the cooperative agreement award number 1U61TS000117-05 from the Agency for Toxic Substances and Disease Registry (ATSDR). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.