A network of experts in reproductive and children’s environmental health

PEHSU Grand Rounds Webinar

This webinar is part of an ongoing series of educational presentations by experts on issues that focus on current and emerging aspects of pediatric and reproductive environmental health.

Prenatal toxicant exposure and ovarian aging and cancer - January 27, 2016

These presentations focus on the impact of environmental exposures to chemicals on human health at the vulnerable stages of in utero and pediatric development. A number of topics will be included – all of them relevant to questions of exposure and health effects, with consideration of risk reduction. Speakers will include physicians and PhD subject matter experts, as well as individuals with expertise in areas such as home assessment, laboratory analysis, and risk communication.

Learning Objectives

At the conclusion of this activity, attendees should be able to:
  • Understand the critical events during ovarian development and their timing.
  • Review the experimental and epidemiological evidence that exposure to environmental toxicants can lead to accelerated ovarian aging and ovarian tumors in adulthood.
  • Understand what is known about mechanisms by which prenatal exposures to toxicants cause ovarian failure and ovarian tumors and understand key data gaps.

Presented By: Ulrike Luderer, MD, PhD, MPH

Luderer_photo_2013.jpgUlrike Luderer, MD, PhD, MPH
University of California, Irvine
Irvine, CA
Dr. Ulrike Luderer is Professor of Medicine in the Division of Occupational and Environmental Medicine and Director of the Environmental Health Sciences Graduate Program at the University of California at Irvine. She also holds joint appointments in the Department of Developmental and Cell Biology and the Program in Public Health at UC Irvine. She earned a Ph.D. in Reproductive Endocrinology and M.D. from Northwestern University, and M.P.H. from the University of Washington, and is board-certified in Internal Medicine and in Occupational and Environmental Medicine.  Dr. Luderer's research focuses on mechanisms of action of reproductive toxicants with a particular emphasis on oxidative stress as a mechanism of ovarian toxicity. Her recent and ongoing work investigates the interactions between genetic deficiencies in antioxidant capacity and toxicant exposure in ovarian toxicity, reproductive aging and ovarian cancer. Dr. Luderer has served on the Scientific Guidance Panel of the California Environmental Contaminant Biomonitoring Program since 2007, including 5 years as Chair. She also currently serves on the California Developmental and Reproductive Toxicant Identification Committee.  She previously served as a member of the Environmental Health Committee of the Science Advisory Board of the US Environmental Protection Agency. She served on the National Toxicology Program/NIEHS Center for the Evaluation of Risks to Human Reproduction Expert Panel on 1- and 2-Bromopropane and chaired the Expert Panel on styrene.

Webinar Recording and Materials 

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This material was supported by the American College of Medical Toxicology (ACMT) and funded (in part) by the cooperative agreement FAIN: U61TS000238-02 from the Agency for Toxic Substances and Disease Registry (ATSDR).

Acknowledgement: The U.S. Environmental Protection Agency (EPA) supports the PEHSU by providing partial funding to ATSDR under Inter-Agency Agreement number DW-75-95877701. Neither EPA nor ATSDR endorse the purchase of any commercial products or services mentioned in PEHSU publications.

Continuing Education 

To receive continuing education (CE):
FEES: No fees are charged for CDC’s CE activities.


CME activities with Joint Providers: This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of the Centers for Disease Control and Prevention and the American College of Medical Toxicology. The Centers for Disease Control and Prevention is accredited by the (ACCME®) to provide medical education for physicians. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Regarding WC2588 - The Centers for Disease Control and Prevention designates this live educational activity for a maximum of 1.0 AMA PRA Category 1 Credits™.

Regarding WD2588 - The Centers for Disease Control and Prevention designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™.

Other Credit types:

  • CNE: The Centers for Disease Control and Prevention is accredited as a provider of Continuing Nursing Education by the American Nurses Credentialing Center's Commission on Accreditation.This activity provides 1.0 contact hours.
  • CEU: The Centers for Disease Control and Prevention is authorized by IACET to offer 1.0 CEU's for this program.
  • CECH: Sponsored by the Centers for Disease Control and Prevention, a designated provider of continuing education contact hours (CECH) in health education by the National Commission for Health Education Credentialing, Inc. This program is designated for Certified Health Education Specialists (CHES) and/or Master Certified Health Education Specialists (MCHES) to receive up to 1.0 total Category I continuing education contact hours. Maximum advanced level continuing education contact hours available are 0. CDC provider number 98614.
  • For Certified Public Health Professionals (CPH)
    CDC is an approved provider of CPH Recertification Credits by the National Board of Public Health Examiners. Effective October 1, 2013, the National Board of Public Health Examiners (NBPHE) accepts continuing education units (CEU) for CPH recertification credits from CDC. Please select CEU as your choice for continuing education when registering for a course on TCEOnline. Learners seeking CPH should use the guidelines provided by the NBPHE for calculating recertification credits. For assistance please contact NBPHE at http://www.NBPHE.org.

DISCLOSURE: In compliance with continuing education requirements, all presenters must disclose any financial or other associations with the manufacturers of commercial products, suppliers of commercial services, or commercial supporters as well as any use of unlabeled product(s) or product(s) under investigational use.

CDC, our planners, presenters, and their spouses/partners wish to disclose they have no financial interests or other relationships with the manufacturers of commercial products, suppliers of commercial services, or commercial supporters with the exception of Charles A. McKay and he wishes to disclose that he is a member of the Scientific Advisory Council, Environmental Health Research Foundation (EHRF). EHRF addresses issues related to biomonitoring, a topic that is also relevant to some of the activities in the Grand Round Series that might be discussed in future sessions. EHRF receives funding from sources that includes industry. Dr. McKay has reviewed and written material for EHRF, that could create a perceived conflict of interest regarding environmental chemical exposure assessment/measurement.

Planning committee discussed conflict of interest with Dr. Charles A. McKay to ensure there is no bias. Content will not include any discussion of the unlabeled use of a product or a product under investigational use. CDC does not accept commercial support.